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From nps.gov: Amistad National Recreation Area is located on the US and Mexico border near Del Rio, Texas and is between San Antonio and Big Bend National Park. The park is 150 miles west of San Antonio on US Highway 90, and about 250 miles east of Big Bend via US Highways 90 and 385. Access to Amistad from the north or south is on US Highways 277 and 377.