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From the BLM site:
Use Interstate 8 to Yuma, AZ. Take the 4th Avenue exit to Imperial County Road S-24. Go north approximately 22 miles to Senator Wash Road. Turn onto Senator Wash Road and follow it for approximately 3 miles to the South Mesa campground. Turn left, then proceed straight through the campground until arrival at the directional signing which will provide directions to Fergusen Lake. Access to Ferguson Lake can also be accomplished by traveling the Colorado River to river mile 57.5 then entering the narrow channel.