I've been running Nanofil for most of this season and I'm impressed so far. I started with 10lb for walleye fishing as I wasn't certain how well the line would hold up. After a few weeks, I stepped down to the 8lb, knowing it would be dependable. I have had no problems with knots slipping, though others have reported this as an issue. The fluorocarbon leader ALWAYS breaks before the 8lb or 10lb Nanofil. I have broken the 8lb once, but I was hooked into a rather large channel cat and it ran me over (I.e. through) an underwater rock bar, significantly damaging the front stretch of my line before it snapped. In that instance, I was not using a leader. The 8lb is fat more subject to abrasion than the 10lb.
Unless the water VERY high turbidity, I use 6'-8' of 8lb p-line fluorocarbon for a leader. The line itsself is a bright, opaque white that is highly visible in the water. Strikes drop ~75% when not using a leader in even moderately turbid water. The white coloration remains visible in low light conditions, making it very good when watching the line for strikes, especially when a lure or bait is dropping right after the cast.
This stuff casts an exceptional distance once it is broken in. The casting distance isn't that impressive right out of the package though.
Strike detection is on par with other "superlines".
There is a bit of a learning curve with this line. When using bait, even with a leader to absorb a bit of shock, casts must be a bit on the gentle side to avoid casting your bait off. This line can also be somewhat challenging to handle in winds above ~15mph, especially when it blows perpendicular to the direction you are casting in.
This is the only "superline" I've tried that actually handles like fishing line. I'm sold on this line.
Edit: I should mention Nanofil has a specific gravity of ~1.2, so it sinks VERY slowly.
