A couple years ago someone gave me his advice on this website and I have been catching lakers at Jefferson ever since. So I'll pay it forward.
Note, there are lots of guys who do way better than I do at Jefferson but here is my approach...
I vertical jig and use a 2-1/2" - 3" white or glow tube jig tipped with sucker meat (get sucker meat at Bass Pro, Sportsmanís Warehouse, Discount Tackle). I like to use the shorter-hook length jigs with at least a 1/4 oz weight. Sharpen the hooks before you go. I use braid (10 lb test) with a long flouro leader (I use 6 feet of 6 lb test). The braid will telegraph the laker's very light hits quite well and the flouro is fairly stealthy near your jig. I use a 7' med weight, fast action rod w/ a 3000 size spining reel...basically a walleye setup.
Try to cut the sucker meat so each piece of fish has some skin on it. Hook the meat through the skin...it will stay on longer. Bring plenty of meat and change up the bait every time you bring up your lure as the meat gets water logged fairly quickly. Little pieces work fine...you don't have to load the hook up...but keep it fresh.
If I have a choice, I target fish 60' deep or less. They seem to be more active the shallower they are. IMO, depth is more important than location on this lake but good places to try are past the point you see as you look to the right (east) side of the lake from the boat ramp. Also I usually find fish out a little way out from the mouth of the other (non-boat ramp) parking area bay.
If you have a fish finder...look for fish and depth (duh). If not, I'd start on the bottom and work my up a couple cranks at a time. Pay attention..the strike often feels more like weight on yout rod...rather than a violent hit. Set the hook well, keep your rod tip up (etc.) as you have 50+ feet of reeling to do.
I hope some of this is helpful to you.